The Genome Database of Born in Guangzhou cohort study (GDBIG) is a biobank of Chinese birth cohort, providing genetic and phenotypic information from thousands of trios/duos families recruited by the [BIGCS Project](http://www.bigcs.com.cn/) in Guangzhou, China. The Phase I study includes 332 trios (father-mother-offspring), 1,406 duos (14 father-offspring and 1,392 mother-offspring) and 245 single individuals (70 children, 150 adult females and 25 adult males), for a total of 4,053 individual samples. Each of the samples was whole genome sequenced to 4-7x. The GDBIG delivers periodical and useful genetic variation information and scientific insights derived from the analysis of the sequencing data. The results aim to promote genetic research and precision medicine actions in China. The delivering information includes the detected variants and the corresponding allele frequency, functional annotation, and frequency comparison to the global populations, etc.
DatabaseYou can search for variants, genes or genomic regions from which you expect to obtain variant information, including mutations, allele frequencies, annotations, and compare frequencies with the overall population in the existing database.
API AccessUsers who register on this website can apply for a private API, and after approval, users can use the API and GDBIGtools to retrieve GDBIG data in command line mode, which greatly improves your data processing efficiency.
Imputation serverProvides a genotype imputation service base on the reference panel of BIGCS. You can upload phased or unphased genotype data (VCF format) and receive a phased and imputed VCF in return.
GWAS meta-analysisAim to perform meta-analysis of the results of GWA studies of binary or quantitative phenotypes. Fixed- and random-effect meta-analyses are performed for both directly genotyped and imputed SNPs using estimates of the allelic odds ratio and 95% confidence interval for binary traits, and estimates of the allelic effect size and standard error for quantitative phenotypes.
The Born in Guangzhou Cohort Study Department is the main department to undertake key project ‘The Born in Guangzhou Cohort Study’,improving child and women's health interventions to provide a scientific basis, and provide the basis for improving health services, the development of relevant medical service guidelines and policies.