出生队列研究室是承担广州市重点科技项目“广州出生队列研究”的主要部门。项目拟对在广州市分娩的30 000名孕妇及其所生儿童进行长期的随访,并建立中国最大的正常人群亲子生物样品库,运用流行病学研究方法,探讨未来20年中,影响广州地区儿童和妇女健康的主要因素,测量社会、经济、文化、生物、环境等因素在影响这一弱势群体中的作用及其作用机理,从而验证一系列不良妊娠结局和儿童期疾病的病因假设,为提出改善儿童和妇女健康状况的干预措施提供科学依据,同时为改善医疗卫生服务,制定相关的医疗服务指南及政策提供依据。

广州出生队列基因组数据库 (GDBIG) 是一个中国出生队列生物库,包含了 [BIGCS项目](http://www.bigcs.com.cn/) 所招募亲子对的基因型和表型信息。第一阶段纳入了332个家系样本(父-母-小孩),1,406 个配对样本 (14 个父亲-小孩对和 1,392 个母亲-小孩对),以及 245 个没有血缘关系样本(70个小孩,150个成年女性和25个成年男性),总共4053个个体样本,每个样本都进行了 4-7x 的全基因组测序。GDBIG 提供了有用的变异信息、GWAS结果和科学见解,并将定期更新。这些结果旨在促进中国的基因研究和精准医学,数据库中所提供的信息包括了任何检测到的变异以及相应的等位基因频率、注释信息、以及与现有全球其他人群的频率比较等。

The Born in Guangzhou Cohort Study Department is the main department to undertake key project ‘The Born in Guangzhou Cohort Study’ in Guangzhou City. This project intends to invite 30 000 pregnant women and their children to have a long-term follow-up, to establish the largest biological parentage biobank in normal population in China, using epidemiological methods to explore the impact of the Guangzhou area in the next 20 years, find out the main factors of children and women's health, measuring the social, economic, cultural, biological, and environmental factors, and the mechanism of them, as well as to verify the cause of a series of adverse pregnancy outcomes and childhood diseases, improving child and women's health interventions to provide a scientific basis, and provide the basis for improving health services, the development of relevant medical service guidelines and policies.

The Genome Database of Born in Guangzhou cohort study (GDBIG) is a biobank of Chinese birth cohort, providing genetic and phenotypic information from thousands of trios/duos families recruited by the [BIGCS Project](http://www.bigcs.com.cn/) in Guangzhou, China. The Phase I study includes 332 trios (father-mother-offspring), 1,406 duos (14 father-offspring and 1,392 mother-offspring) and 245 single individuals (70 children, 150 adult females and 25 adult males), for a total of 4,053 individual samples. Each of the samples was whole genome sequenced to 4-7x. The GDBIG delivers periodical and useful genetic variation information and scientific insights derived from the analysis of the sequencing data. The results aim to promote genetic research and precision medicine actions in China. The delivering information includes the detected variants and the corresponding allele frequency, functional annotation, and frequency comparison to the global populations, etc.

gdbig_notice@bigcs.org Address: 9 Jinsui Road, Tianhe District, Guangzhou 510623, China.